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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of design that include recruitment and consent, adherence and the use of standard equipment.

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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for a pragmatic trial to be valid and lessen the chance of bias is also essential. However too much heterogeneity could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to inform their decision making. They are also a good method of determining the causality between the intervention and its effects. However, they shouldn't be used in lieu for explanatory trials.

The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as a complement to them. Schwartz and 프라그마틱 환수율 Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which inform the policy and practice of. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a practical trial that include the recruitment process, the design and delivery of the intervention, as well as monitoring.

There is a positive increase in the number pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatics. It is important to note that the majority of these studies were conducted in primary care settings.